The misuse of opioids, including prescription pain relievers, heroin and synthetic opioids such as fentanyl, is a serious United States national public health crisis that affects both social and economic welfare. Recent estimates indicate that 11.4 million Americans, or about 4.2% of the total population, misuse opioids. About 80% of individuals using heroin (almost 900,000 individuals) first started out using prescription opioid pain relievers. The Centers for Disease Control and Prevention estimates that the “all-in” annual cost of opioid misuse in the United States is $78.5 billion, which includes the costs of healthcare, lost productivity, addiction treatment, and criminal justice involvement. There are multiple medications currently approved to treat Opioid Use Disorder (OUD) but given the scope and impact of this national public health crisis as well the limited success of current medicines, additional solutions are needed. The best predictor of long term recovery and relapse prevention is for OUD patients to take their medication and to remain on it.